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KMID : 0359919930120010062
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Korean Journal of Nephrology
1993 Volume.12 No. 1 p.62 ~ p.67
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Effect of Recombinant Human Erythropoietin on Cardiac Function and Morphology in Patients with Chronic Renal Failure
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박원도
송일한/강흥선/안재형/이태원/임천규/배종화/김명재
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Abstract
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Background:
@EN Hemodynamic changes often occur in patients with chronic renal failure. Hyperdynamic state is probably contributory determinent of the congestive uremic cardiomyopathy in these patients. Renal anemia is the most important factor in these
changes.
@ES Methods:
@EN Using echocardiography, we evaluated the hemodynamic changes in thirteen patents with severe renal anemia (Hct<23%) before and after treatment with recombinant yhuman erythropoietin (rHuEPO). Thirteen patients on maintenance hemodialysis were
treated with rHuEPO 50IU/kg intravenoucly three times per week for twelve weeks.
@ES Results:
@EN Under rHuEPO treatment, hematocrit rose from 19.8±1.8% to 30.4±2.5% Up<0.01) and blood pressure significantly increased (p<0.05). left vetricular dimension and volume were decreased but not significantly. Cardiac wall thickness was
unchanged
during study period. Posttreatment cardiac index was decreased (5.5±1.6 vs 4.3±1.3 liter/min/m2) when compared with pretreatment period (p<0.05).
@ES Conclusion:
@En This study suggested that partial correction of renal anemia by rHuEPO terapy results in improvement of hemodynamic impairment in patients with congestive uremic cardiomyopathy. The decreases of cardiac index might well be a result of
improved
cardiac funtion and pe4ripheral vasoconstriction due to increased oxygen availability.
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KEYWORD
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